NAD Therapy for addiction and aging | 703-844-0184
NAD stands for nicotinamide adenine dinucleotide, which is the chemical term for a molecule that reacts with oxygen in the mitochondria in every cell of your body in order to create energy so you can move, breathe, pump blood, digest food, think, and generally, live your life.
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Lack of this essential cellular fuel is now recognized as a key feature of chronic fatigue, apathy, depression, anxiety, alcohol and drug addiction, weak immune system (infections and cancer), muscle pain and weakness, headaches, memory disturbance, sleep problems, focus and concentration defects and other chronic diseases. NAD deficiency may be an unrecognized epidemic of cellular disease.
NAD is an activated form of vitamin B3 which becomes a coenzyme when it is bound with hydrogen becoming NADH. Hydrogen, as in hydrogen bomb, is the explosive power that the body uses, along with oxygen, to make energy. Liquid hydrogen and liquid oxygen explode when blended together becoming the fuel that propels rockets into the sky. Hydrogen is so explosive that it must be safely inserted into a molecule so that it can be used by the body. NAD is the carrier for reactive hydrogen as it becomes NADH.
This is how it works. We eat carbohydrates, proteins and fats which provide the chemicals that enter the Citric Acid Cycle, a molecular roundabout that produces NADH. The NAD is now “loaded” with hydrogen (NADH) which in turn enters the electron transport chain in the mitochondria and is “sparked” with oxygen and the outcome is energy, or, ATP, along with water. ATP, or adenosine triphospate, is the fuel for the heart to beat, the muscles to contract and for every cellular energy requirement with in the 100 trillion cells of the body.
It is clear to see how important NADH is for the body as it is involved in every bodily function and catalyzes more than a thousand metabolic reactions in the organs and tissues. The heart uses the most NAD as it beats around 86,000 times daily. The brain consumes about one-third of all the energy produced by the body. Often an energy deficiency is first detected in the brain with poor concentration, difficulty focusing, and attention deficit. If the energy shortage lasts long enough, brain neurons cannot synthesize neurotransmitters, the molecules of consciousness, such as serotonin, dopamine, and noradrenaline, and we experience anxiety, depression, sleep disturbance and other mood changes.
Let us take a look at some of the functions of NADH in the body:
- Increases energy in heart cells
- Increases energy in brain cells
- Protects and repairs DNA, reducing DNA mutations which contribute to atherosclerosis, cancer, immunodeficiency, rheumatoid arthritis, and much more
- The “most powerful antioxidant” in the body according to Dr. Richard Passwater in his book NADH-The Energizing Coenzyme NADH-the-energizing-coenzyme
- Lowers cholesterol
- Lowers blood pressure
- Strengthens the immune system
- Stimulates production of dopamine, serotonin, and noradrenaline, thereby improving moods
- Stimulates nitric oxide production, thereby improving blood flow in the body
Medical research has shown the following medical conditions to improve with NAD therapy:
- Chronic fatigue
- Muscle pain and weakness
- Joint pain and stiffness
- Alcohol and drug addiction
- Sleep disturbance
- Memory loss (forgetfulness)
- Attention deficit
- Fevers, sore throats and swollen lymph glands
- Parkinson’s disease
Research has also shown that NAD can provide the following benefits in “healthy” people:
- Increased physical energy
- Improved mental performance
- Improved response to short term sleep deprivation
- Reduce the effects of jet lag
- Enhance libido
Since NAD is so fundamental to good health, how is it that we can become deficient in this powerful molecule?
First of all, the vitamins, minerals, complex carbohydrates, proteins and fats come from our diet and provide the building blocks to citric acid cycle energy production. If any one of the nutritional factors is low, energy production is weakened. Since oxygen is just as important as hydrogen in cellular energetics, lack of exercise and shallow breathing due to stress are common factors that can reduce the amount of oxygen at the cell level. And finally the enzymes that catalyze the citric acid cycle are often inhibited or destroyed by chemical or physical toxins that create oxidative, or free radical, damage.
Free radical damage comes from cigarette smoke, drugs, radio waves from cell phones and wi-fi, and the myriad chemicals found in all humans at this time on earth, including phalates, parabens, pesticides, styrene, benzene, toluene, and thousands more. For example, medical scientists now widely believe that Alzheimer’s dementia and Parkinson’s disease share the common feature of nerve cell degeneration due to impairment of the ATP producing enzymes with the citric acid cycle and mitochondria.
However, there is more than acquired NAD deficiency, due to poor diet, chronic stress, sedentary living and toxin accumulation so common in our modern world – it may also be genetic for some people. Genetic NAD deficiency may be present at birth and appear in children as poor sleeping, behavioral problems, hyperactivity, impaired concentration, academic stress and underachievement.
Some people have been tired and depressed for as long as they can remember. For these people there is a greater tendency to try drugs and alcohol in order to improve energy and mood, and simply feel better, but the risk for addiction is high. I have treated several people addicted to drugs, alcohol or medical drugs such as benzodiazapenes, like Valium, Librium and Klonopin, with intravenous NAD, thereby eliminating the addiction and leading to improved energy and moods in the long run.
Genetic disorders in energy production are complex and the research is accumulating to help us understand this important issue. There may be a genetic polymorphism that reduces a gene coding for a mitochondrial protein. Since mitochondrial DNA is all received from the mother through the egg (no mitochondria are found in sperm) we can look to the maternal side for clues to energy production in the family history.
How do we diagnose NAD deficiency? Fatigue is often the first signal, but there are many conditions in the body that present as fatigue, such as low thyroid. The following clues are used in making a diagnosis of NAD deficiency:
- Fatigue and depression, mainly on the mother’s side
- Fatigue and/or depression beginning early in life, such as childhood or teen years
- Alcohol or drug addiction
- Chronic fatigue any time in life
- Depression and anxiety
- Almost any chronic disease
Traditional blood tests
- Lactic acid and pyruvate (blood):
- Pyruvic acid comes from foods and supplies energy to the citric acid cycle when oxygen is present and alternatively ferments to produce lactic acid when oxygen is lacking (fermentation). Therefore elevated lactic acid or pyruvate may be a signal of NAD deficiency.
Specialty lab tests
- Organic Acid testing (urine) is available from Genova Diagnostics, Great Plains Laboratory and Metametrix Clinical Laboratory:
- Pyruvate and lactic acid can also be measured in a first-morning urine.
- Citric Acid Cycle Intermediates are organic acids found in the urine that directly reflect CAC activity and when elevated indicate CAC dysfunction and reduced NADH. There are many metabolic reasons for elevated CAC intermediates.
- Citric Acid Cycle Intermediates include the following:
- Citric acid
- Cis-Aconitic acid
- Isocitric acid
- Alpha-ketoglutaric acid
- Succinic acid
- Malic acid
- Beta-hydroxy-beta-methylglutaric acid
How do you treat NAD deficiency?
First of all NAD is in many of the foods that we eat, but it is mostly lost in cooking and what little remains is broken down by the acid in our stomachs. Many research scientists have observed that NAD is oxidized and degraded before it is absorbed from the digestive tract. More recent studies have shown that NAD can be provided in a stabilized form and will increase ATP production in the body and in the brain, thereby offering hope to patients with neurodegenerative disorders.
For patients with severe NAD deficiencies, such as alcoholics or drug addicts, the intravenous form has been shown to be highly effective, usually eliminating the physical craving within three or four days and then producing a clarity of thinking with continued daily IV therapy. The cognitive and emotional improvement is likely due to increased production of neurotransmitters such as serotonin, noradrenalin and dopamine. Numerous studies have shown that IV NAD is highly beneficial for drug addicted patients, including those addicted to benzodiazepine medications like Valium, Librium and Klonopin.
Intravenous therapy for four to six days is often beneficial to people with chronic depression, often unresponsive to antidepressant therapies.
There is now a new form of oral NAD that is proving highly beneficial to patients with NAD deficiency and the widespread problems with adequate cellular energy production.
In the future, NAD therapy will likely prove beneficial for a range of common medical problems, including fatigue, jet lag, mood disorders, menopausal symptoms, obesity and more. Like aerobic exercise and healthy whole food nutrition, NAD therapy offers a foundational treatment that promotes health throughout the body.
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Marlene Prendeville’s interview at the A4M Expo following her meeting with Dr Richard Passwater Ph.D. Director, Selenium Nutritional Research Center
Marlene Prendeville met Dr Richard Passwater Ph.D. Director, Selenium Nutritional Research Center at the A4M Winter 2014 expo and conference in Las Vegas and requested his thoughts on Pycnogenol and Selenium.
Dr Passwater said: “ First, I wish to confirm that I am in full agreement with the remarks submitted by Carolina Burki-Sozzi below. Second, I wish to make clear that I have never been affiliated with Horphag Research.
My research and writings are and have been independent of Horphag Research. I am the Director of Research at the Selenium Nutritional Research center in Berlin, MD. I have written five books on selenium and six books on Pycnogenol.”.
Below are some of Marlene Prendeville’s questions and Dr Passwater’s responses:
What are Dr. Richard Passwater’s views/recommendations on Pycnogenol and Selenium and their contribution towards the aging process?
“Selenium is a dietary essential nutrient involved in many health and anti-aging mechanisms in the body primarily because it is an essential component of several selenoprotein enzymes that help protect against several major deleterious reactions and diseases of the aging process.
Pycnogenol is a specific and patented mixture of nutrients consisting largely of the Bioflavonoid family and its derivatives and oligomers. These nutrients can influence the expression of genes and influence fundamental aspects of cellular function. Thus, Pycnogenol can “turn on” and “turn off” specific genes in such a way as to determine our health and aging.”
Dr. Carolina Burki-Sozzi has cited specific studies indicating how Pycnogenol contributes to healthy aging of several body systems. I will discuss just one example of how Pycnogenol supports a healthy cardiovascular system because covering more systems would require a book. Incidentally, my latest book, co-authored with Professor Peter Rohdewald, has just been printed. (The Pycnogenol Phenomenon” Ponte Press Verlags-GmbH, Bochum, Germany)
Dr Passwater claims Pycnogenol has several modes of action in protection against cardiovascular disease. Pycnogenol helps prevent the blood clots that form in narrowed arteries that cause heart attacks and strokes. It does this by normalizing blood platelet activation by blocking the production of excess thromboxane. This keeps the blood slippery and free of blood clots.
He says: Pycnogenol also reduces chronic inflammation and LDL-cholesterol (bad cholesterol), while increasing HDL-cholesterol (good cholesterol). Pycnogenol helps regulate the inflammation master switch, NF-. B. The less inflammation, the less risk of atherosclerosis (narrowed arteries due to deposits).
Another important mode of action of Pycnogenol is the protection of the lining (endothelium) of the artery walls. Pycnogenol acts as a catalyst for the enzyme that produces nitric oxide in the artery walls. This keeps the arteries open and flexible, better able to prevent deposits and normalize blood pressure.
Pycnogenol helps prevent damage to blood vessels caused by free radicals and other reactive species including elevated blood sugar. This means less damage to the heart, arteries, nerves and all organ systems. It is not the passage of time alone that causes aging. It is the damage that occurs to organs caused by oxidation, radicals and sugar that ages organ systems.
Should older women and men in their 70s take the above two products on a regular basis to stave off and protect against Colon Cancer and other diseases?
“For optimal health, all persons should take optimal amounts of selenium and Pycnogenol. The sooner one optimizes his or her diet, the longer the protection will be in place. The non-germ diseases associated with aging usually develop over decades. These diseases include most cancers, heart disease, dementia, arthritis, and many, many more.”.
Does Dr. Passwater recommend any products for Memory and Brain Focus which women and men in their 70s could take as part of their everyday diet as they approach aging?
Several nutrients have been shown to improve memory and focus associated with aging. Important, but not limited to, are EPA and DHA (as from fish oil for example), phosphatidylserine, Pycnogenol and Selenium.
I myself and many of my readers would like to try out Pycnogenol and Selenium for prevention of Colon Cancer – please let me know how I will be able to obtain these two products and also the Memory and Brain Focus in 3. above.
Dr Passwater replied: “Early epidemiological studies suggested that selenium greatly reduced the risk of colon cancer in those not adequately nourished with selenium. A recent clinical trial with men already receiving adequate intakes of selenium found no difference when additional selenium was taken. This trial does not support the earlier findings. At this time, vitamin D and calcium appear to be the best nutrients to protect against colon cancer.
More studies are needed, but in the meantime, it seems prudent to optimize vitamin D, calcium and antioxidant nutrient intakes.
World Health Net
Piping Rock Nutrition
What is NAD+?
NAD+ stands for nicotinamide adenine dinucleotide. NAD+ is a molecule synthetized de novo from tryptophan or from the recycling of nicotinamide, salvaged from the degraded NAD+ molecule. NAD+ is found in each cell of our body under its oxidized form NAD+ or its reduced form NADH. It donates or receives an electron in redox reactions without being consumed, constantly cycling between its 2 forms: NAD+/ NADH. NAD+ was first identified as an important coenzyme in glycolysis, the energy producing metabolic cycle of the cell, therefore its other name, Coenzyme 1. Today, research has shown that NAD+ regulates many metabolic functions, in particular DNA repair and transcription. Research has shown that a decreased ratio of NAD+ to NADH is associated with chronic illness, ageing and the metabolic and behavioral changes associated with alcoholism and addiction.
NADH/NAD+ Therapeutic Uses
NADH is used orally to increase ATP, the energy currency of the cell produced in the Krebs cycle. NADH has proven to be useful in the following conditions: Parkinson disease, chronic fatigue, Alzheimer’s disease, depression and anti-aging. NAD+ is used to improve the ratio of NAD+ to NADH in drug and alcohol abuse. Increased levels of NAD+ speed up brain cell repair. NAD+ has been used intravenously in holistic addiction therapy to improve physical recovery at the molecular level, as a part of a wider approach including spiritual, mental and emotional changes.
History of NAD
Dr. Hitt Neurotransmitter Restoration Therapy (NRT)
After many years of research on the use of amino acids, minerals and vitamins to speed up the detoxification process from opiates, alcohol and other drugs, Dr. William Hitt, an American doctor and scientist, created a protocol for drug addiction recovery, known as Neurotransmitter Restoration Therapy, (NTR). This protocol addressed the neurotransmitter depletion and neurotransmitter receptor damage due to drug or alcohol overuse. Drugs produce their psychological effect by mimicking brain neurotransmitters, either by plugging into the receptor site or modifying the receptor site itself. When drug abuse ceases, the brain recovers on its own, but it may take up to a year or more. Dr. Hitt protocol speeds up this recovery time, therefore reducing the possibility of relapse due to cravings. Studies found that his protocol not only reduces cravings but limits side effects of drug withdrawal and promotes long term recovery.
Research on NRT
In the 1980’s with the support of the World Health Organization, Dr. Hitt, conducted a clinical trial in his clinic in Mexico. He administered his Neurotransmitter Restoration Therapy protocol to 3000 patients and follow them up for 3 years. After 3 years, 70 per cent of them were still sober, 2 to 7 times higher than the recovery rate of conventional approaches. After being forgotten for several years after his death, the Neurotransmitter Restoration Therapy, is coming back to life with those who worked with him and are now popularizing his treatment. NAD+ is used, not only for recovery from addiction, but also for PTSD, anxiety and depression, chronic illness and anti-aging.
“NAD has emerged as a putative metabolic regulator of transcription, longevity and several age-associated diseases, including diabetes, cancer and neurodegenerative diseases”. Nicotinamide adenine dinucleotide, a metabolic regulator of transcription, longevity and disease Su-Ju Lin and Leonard Guarente Current Opinion www.current-opinion.com
NAD+ is administered intravenously over 10 consecutive days. The duration of the drip, up to 5 hours or more, varies according to the dosage and individual tolerance. NAD+ may be preceded by a Myers cocktail or a magnesium push to increase its tolerance and it is followed by a drip combining amino acids, vitamins and minerals, essential to neurotransmitter’s synthesis.
How Does NAD Work?
NAD+ / NADH and Brain Repair
NAD+ is absorbed by the astrocytes in the brain. Astrocytes have the important role, among many other functions, to provide nutrients to repair neurons after traumatic injury. Recent studies have shown that the administration of NAD+ can decrease ischemic brain injury. Increased levels of NAD in the neurons protects against degeneration
“Our latest studies have suggested that NADH can be transported across the plasma membranes of astrocytes, and that NAD+ administration can markedly decrease ischemic brain injury”.
[Study link: PMID: 17127427 Front Biosci. 2007 Jan 1;12:1863-88. “NAD+ and NADH in brain functions, brain diseases and brain aging.” Ying W., Front. Biosci. 2007; 12:1863 – 88.]
NADH can be transported across the plasma membranes of astrocytes
NAD+ has a Neuroprotective Effect Against Axonopathy
“Axonopathy is a critical early event in distinct degenerative conditions including Alzheimer’s disease(AD), Parkinson’s disease and multiple sclerosis (MS),and it occurs in response to infections, alcoholism, acute chemotherapy-associated toxicity, diabetes and normal aging ”
NAD+ metabolism in health and disease, Peter Belenky, Katrina L. Bogan and Charles Brenner* TRENDS in Biochemical Sciences Vol.32 No.1
NAD+ and the Biology of Addiction
The compulsive need to consume a substance despite its negative health and social consequences can be viewed as the behavioral result of a neurological disorder in which the deep part of the brain is no longer controlled by the cortex. (Those deep changes in the brain have been demonstrated by MRI). All addictive substances, regardless of their behavioral effect, high, euphoria or sedation, activate the dopamine reward system of the brain and repeated use induce molecular and cellular changes in this system leading to adaptation and dependency. This biological process is the target of NAD+ administration.
NAD and Alcoholism
Alcohol is processed mostly in the liver. The first step in alcohol metabolism is the oxidation of ethanol to acetaldehyde and NADH catalyzed by the enzyme alcohol dehydrogenase containing NAD+. Acetaldehyde is a toxic compound that eventually harm the mitochondria and the liver.
CH3CH2OH + NAD+ —> CH3CH=O + NADH + H+
Large consumption of alcohol produces an excess of Acetaldehyde and NADH that cannot be processed by the liver to the final form of acetic acid. Some acetaldehyde and NADH escape in circulation and reaches the brain where it alters neurotransmitters and causes the known behavioral effects of alcohol intoxication. The excess of acetaldehyde and NADH in the liver is the cause of the metabolic effects of alcohol: hyperglycemia or hypoglycemia depending on whether glycogen stores are adequate, inhibition of protein synthesis, elevations of triglycerides which accumulate in the liver resulting in fatty liver and hyperlipidemia. The elevated ratio of NADH to NAD and elevated acetyldehyde is also the cause of the addictive effect of alcohol as demonstrated by recent studies.
“Recent investigations have suggested that acetaldehyde may be responsible for the development of alcohol addiction. Acetaldehyde in the brain may inhibit enzymes designed to convert certain nerve transmitters from aldehydes to acids. The nerve transmitters that accumulate may then react with the acetaldehyde to form compounds which are startlingly similar to certain morphine-type compounds”.
A number of metabolic and psychological effects from alcohol are directly linked to the production of an excess of both NADH and acetaldehyde.
NAD+ and Cravings
Cravings combined with the lack of control of the cortex over impulsivity lead to relapse. The biology of cravings is deeply seated in the brain neuronal circuits changes in response to chronic drug use. Studies have shown that NAD+ can help repair these circuits and reduce drug cravings
The following study was conducted about the effect of NAD+ on addiction –
500 mg to 1500mg of NAD+ was administered to 60 patients for 10 days daily over a period of time of 5 to 10 hours. Cravings were rated at the beginning of the treatment, at 5, 10 days and 12-20 months.
The study reports a decrease in cravings for stimulants opiates and alcohol 5 days after the starting of the treatment
of excess NADH generated by ethanol oxidation
In our effort to provide the most innovative, advanced, and effective therapies to promote healing of the body, mind and spirit, we now turn our attention to NAD BR+ (Brain Restoration) therapy. Although not-well known in the medical field, this therapy boasts benefits that include:
- Restoring cellular production of energy (ATP)
- Protecting and repairing DNA (PARP)
- Strengthening the immune system (improved cell signaling of Immune-CD38, CD157)
- Anti-aging impact via increased tankyrase activity / longer telomeres
- Lowering cholesterol and blood pressure
- Stimulating production of dopamine, serotonin, and noradrenaline, thereby improving mood and brain function
- Improving athletic endurance and combating fatigue
To gain more insight on this completely nutrient-based and safe specialized therapy, we turned to one of the pioneers of NAD BR+ Therapy, Richard Mestayer, M.D., of the Springfield Wellness Center, the first and longest operating clinic to provide NAD Brain Restoration Plus treatment (BR+) in the United States.
What is NAD+?
As we grow older, certain genes can be triggered that accelerate degenerative aging processes. This can result in symptoms such as chronic fatigue, loss of mental clarity, depression, stress, anxiety, and various other chronic illnesses. A critical factor in this process is a coenzyme by the name of nicotinamide adenine dinucleotide (NAD+), that enables the transfer of energy from the foods we eat to vital cell functions, especially in the brain. Every cell in the body needs it. This compound is required to “turn off” those genes that accelerate aging. The problem comes when NAD+ levels begin to decline, either due to lifestyle, diet, use of drugs or alcohol, stress, toxins, or a host of other factors.
“NAD+ is probably as important as oxygen to make cells work,” Dr. Mestayer explains. “It’s in every cell of your body; it’s in every mitochondria. It has multiple functions. We’re still learning the new nuances, but it’s important and involved with DNA repair, cellular function including energy production, promoting cell health – that’s why it’s involved in longevity – and immunity. It is involved in a multitude of reactions: redox reactions – it could help reduce oxidized stress – and we think it helps to reduce inflammation generally as well.”
NAD+ is probably as important as oxygen to make cells work.”
Modern Life and the Impact on NAD+Production
The rigors of modern life have taken a toll on the levels of NAD+ in our bodies. Three main factors are to blame for NAD+ deficiencies:
- Stress: We simply can’t seem to escape it in today’s rat race environment. Stress has become common place, with the American Psychological Association linking chronic stress to the six leading causes of death: heart disease, cancer, lung ailments, accidents, cirrhosis of the liver and suicide. Add in oxidative stress, where an imbalance between the production of free radicals and the ability of the body to counteract with antioxidants occurs, and you create an environment where NAD+ is being depleted quite quickly.One such biomarker of oxidative stress is 8-Isoprostane. This prostaglandin-like compound is produced by free radical-catalyzed peroxidation, and has been suggested to be the most reliable approach to monitor oxidative stress. High levels of 8-isoprostane is an indication of oxidative damage and a reduction in available NAD+.
“I think the biggest issue that keeps the levels down is the extreme use of it. If you have a lot of oxidative stress, you’re going to use more and deplete. If you have a lot of DNA repair which happens as you get older, you’re depleted”, says Dr. Mestayer.
- Diet / Alcohol / Drugs: Part of the reason for NAD+ deficiency is that diet and what you put in your body is critical. “You get [NAD] from your diet. The body doesn’t make NAD unless there is something put in like Vitamin B3 or tryptophan,” Dr. Mestayer adds. The modern day diet for most has resulted in the abandoning of traditional, whole foods in favor of modern processed foods high in sugar, refined flour and unhealthy fats.In addition, the use of alcohol and drugs are contributors of NAD+ depletion. Studies have demonstrated the efficacy and safety of IV NAD in detoxifying patients from alcohol, opiates, tranquilizers and stimulants. Clinical experience has shown benefits in greatly reducing withdrawal symptoms, as well as reducing, and often eliminating associated cravings.
- Inflammation: Inflammation has become a major issue and contributing factor in a majority of common chronic conditions. Simply put, inflammation is your body’s response to stress – whether it be from diet, emotions, lifestyle, or environment. One particular component of inflammation that is associated with NAD+ depletion is a glycoprotein called CD38. Found on the surface of many immune cells, CD38 plays an important role in inflammation. CD38 causes migration of neutrophils and monocytes toward sites of inflammation, signals maturation of dendritic cells during inflammatory cytokine activation, and generates Ca2+mobilizing metabolites. To do this though, it must consume large amounts of NAD+.Dr. Mestayer explains: “If you have a lot of immunity issues – there’s a compound called CD38. CD38 is a tremendous utilizer of NAD and it is very much involved in reducing inflammation and bolstering immunity. CD38 is also involved in oxytocin production, so there’s a link between NAD and oxytocin production – which is all new stuff.”
NAD+ and Relation to Other Conditions
Addiction: Restoration of proper brain biochemistry is a major requirement for breaking any addiction, restoring clarity of mind, stabilizing moods, and reducing or eliminating cravings. Dr. Mestayer and Springfield Wellness Center have helped hundreds of patients break free of alcohol and drug addictions with minimal or no withdrawal. According to Dr. Mestayer, “We’ve shown a tremendous reduction in a compound, 8-Isoprostane. It’s a marker for oxidative stress. So we’re actually demonstrating a reduction in oxidative stress in our addiction patients. Nobody has really studied that in addiction patients. We only assumed that.”
Degenerative Diseases: Current research also indicates that NAD deficiencies may trigger a host of metabolic and degenerative diseases—including obesity, Type II diabetes, Alzheimer’s, amyotrophic lateral sclerosis (ALS), and Parkinson’s. NAD+ treatment has been shown to be capable of dramatically reducing related neurological symptoms. Although more research needs to be done, these results are consistent numerous known benefits of NAD + which is an essential component of energy production (mitochondrial function); heavily involved in DNA repair and cell repair; responsible for turning certain genes on and off; and essential for maintaining neurotransmitter levels, for the proper functioning of the brain.
Anxiety, Depression & PTSD: NAD+ is essential for maintaining proper levels of neurotransmitters—intricately involved in brain communications. NAD also plays a role in DNA repair, and in turning genes “off” and “on.” We also know that NAD levels are depleted when the body is dealing with illness, addiction, environmental toxins (including medications) and stress. So, if depression is caused by one or a combination of the following: faulty mood regulation by the brain, genetic vulnerability, stressful life events, medications, and medical problems, it’s likely that NAD plays a role in resetting the brain to regulate moods appropriately and get you feeling good again.
Sleep Disorders: Our sleep and wake cycles are dictated by circadian rhythms. These biological rhythms of life are established and maintained by a central clock consisting of around 20,000 pacemaker neurons in the supra-chiasmatic nucleus (SCN). Along with NAD+, Nicotinamide phosphoribosyltransferase (NAmPRTase or Nampt) helps to drive the circadian clock feedback cycle through SIRT1, a protein also known as NAD-dependent deacetylase sirtuin-1. As levels of NAD+ oscillate over the day/night cycle, the activity of SIRT1 oscillates with it, linking the metabolic state of the cell through an epigenetic mechanism to the circadian clock. Therefore, a deficiency of NAD+ has been associated with circadian dysfunction and sleep disorders.
Autism: NAD has been linked to social behavior as it relates to oxytocin. Through studies in people, researchers have shown that oxytocin plays a vital role in many social behaviors, such as the building of trust between strangers and the bonding between mother and child. Autism, a spectrum disorder (ASD), is characterized by social and communication impairment, and linked to significant defects in the OXT system. Many recent clinical trials have been focused on providing oxytocin nasal spray to improve social abilities, however brain oxytocin secretion is regulated by NAD+ metabolites, and natural supplementation of NAD+ can have a direct impact on OXT release and improvement in social function.
NAD+ and Aging
Compelling research shows that NAD+ has a unique ability to protect tissues, induce DNA repair, and increase life span. To understand how NAD+ can prevent aging, we have to look at an increasing subject of aging – telomeres. Telomeres form the ends of human chromosomes. Without them, DNA strands become damaged and our cells can’t do their job. They basically act as the aging clock in every cell. The issue arises because telomeres shorten with each round of cell division, and shortening can be exacerbated by a number of other influences. Shorter telomeres are linked to an increased incidence of disease and premature cellular aging. Other studies have associated short telomeres with a decrease in bone mineral density in women and immune functioning.
Research has shown the correlation of NAD+ and telomere length. Increased NAD+ availability can increase tankyrase removal of Telomeric Repeat Factor 1 (TRF1). TRF1 is a protein that binds at telomere ends, and is known to protect telomeres from DNA mechanisms that are used for repair purposes and at the same time regulate the activity carried out by telomerase. This action in turn improves telomerase access and elongation of the telomere, which is important in slowing of the aging process.
NAD+ and the Brain
One of the most impacted organs from NAD+ deficiency is the brain. NAD+ plays a vital role in the brain, with a 2007 study stating, “NAD+ and NADH (the reduced form of NAD+) may also mediate brain aging and the tissue damage in various brain illnesses. Our latest studies have suggested that NADH can be transported across the plasma membranes of astrocytes, and that NAD+ administration can markedly decrease ischemic brain injury. Based on this information, it is proposed that NAD+ and NADH are fundamental mediators of brain functions, brain senescence and multiple brain diseases.”
NAD+ helps to replenish the supply of neurotransmitters, improve cognitive functioning, withdraw from addictive substances, overcome anxiety, depression, chronic or acute stress, post-traumatic stress, CTE, and other conditions by giving the brain what it needs to return to proper functioning. NAD+ has been shown to be effective with cases of brain fog, cognitive impairment, and “chemo brain”. It has a powerful capacity to “reset” the brain to its original set point.
That’s the thing we see almost across the board – people feel much more mentally clear.”
» Looking for an oral NAD+ supplement for the brain? Check out our nutraceutical, NADovim®.
How NAD BR+ Therapy is Different
After numerous years of looking for the right formula to maximize delivery of NAD+, NAD BR+ was created. Administered both in intravenous form as well as a nasal spray, the proprietary formula is compounded in a state-of-the-art, FDA-regulated facility, that can only be found in a small number of medical offices in the world and requires special licensing and training. “The thing that distinguishes the NAD BR+ product, and the way the protocols distinguish themselves are the added experience of all the clinicians when we compile information,” states Dr. Mestayer. “For instance, in our protocols now we’re using a lot of Liposomal C. We don’t use the IV C because we’re trying to preserve patients veins because we’re giving them 10 days of IVs and these are people who may have used their veins for IV use. So we have to be careful about that. We’re also using amino acids that we’re blending in.”
The quality and formula separate it from other NAD+ therapies and supplements. As Dr. Mestayer puts it, “Well first of all, it’s the best form of NAD. It’s the most pure that we have been able to find. We have tested every raw material in the world, and it is the purest and the most potent, so to speak. The problem with impurities are….you would be surprised. We found other things like lead and mercury. You know, if you got a 92 percent pure product, what’s the other 8 percent? So this product is 100 percent, maybe 99.9 percent pure. I look at all the certificates of analysis, and the other thing is, the pharmacy sends off 1 vial out of 25 for independent analysis. The standard is 1 out of 300, but they exceed the standard because they know it has to be perfect every time. That’s what sets us apart – the purity of the product and the way we use it in protocols and combinations with other nutrients.”
As for safety and side effects, Dr. Mestayer assures that the completely nutrient-based and natural formula is very safe. “There are not any reports or anything of long-term side effects. There’s a short term effect if the drip is going too fast.” The two areas of precaution are those with MTHFR gene mutations (as there is a methylation issue with high doses of NAD) and patients with bipolar disorder (NAD may activate a manic episode in these patients).