703-844-0184 | NOVA Health Ketamine Treatment Center Fairfax, Virginia 22201 | Peptide therapies |

What are peptides? Peptides are molecules that consist of between two to fifty amino acid sequence. The first commercial peptide therapy used was insulin (1923).

What are peptide therapies? Fundamentally, peptide therapies give cells the ability to change cell behavior and to handle stress better. Peptide therapies are natural modulators of cell signaling. The cell changes behavior and can adjust to stress, aging, etc… and can manipulate the genome with signals going from the mitochondria (where energy is made by the cell) to the nucleus through MOTS-C.  You can get started and just use a growth hormone releasing peptide (GHRP), eg, Ipamorelin by itself without spending a lot of money to see if your sleep improves and bone density improves. Use a GHRP together with bio-identical hormones and get great results.  There are 7,000 natural peptides in the body. There are currently 60 FDA-approved peptides in clinical use. There are now 140 clinical trials happening at this moment in time (October 2018) and there are some 400-500 clinical studies being set up right now. It’s growing into every silo of medicine right now. As a forward-thinking medical practice, we now embrace peptide therapies as an additional mainstay treatment for acute and chronic illness. Our armamentarium of tools has increased. 

Peptide therapies have a variety of applications such as immune enhancement; accelerates injury repair to muscles, reverses sarcopenia (loss of muscle), tendons, bones, nerves; progressive fat loss and improved bone mineral density, increase in Testosterone by increasing pulse size and frequency, decrease inflammation in the brain and the rest of the body, natural release of growth hormone, improves sleep. It’s easiest to think about peptides in these easy to remember ways. Here is how: 1. Hormone optimization, 2. Weight loss, 3. Sexual Functioning, 4. Healing and Repair.

1. Hormone Optimization and Growth Hormone Secretagogues: CJC-1295 without DAC, Ipamorelin, Tesamorelin, GHRP-2, GHRP-6

2. Weight Loss options: GH-191, GHRP, GHRH/GHRP, AOD-9064, Melanotan II, Frag 176-191 (an AOD knockoff, not effective), Thymosin Alpha-1, Cerebrolysin, DSIP, PEPCK, GLP 1R agonist. 

3. Sexual Enhancement and Function: Melanotan II and PT-141.

4. Healing and Repair: GHK-Cu, BPC-157, Thymosin Beta-4, AOD +HA, LL-37, GHRH, MGF and PEG-MGF.

Peptides, as signaling substances, help reclaim efficiency of hormone receptor sites. In other words, if you take some thyroid medicine, eg, T3 (active thyroid hormone), and you don’t see improvement in the labs, it may be that the receptor site is not working properly. Peptides and certain other nutrients can help improve the functionality of the receptor so that the hormones we give work as intended. Importantly, peptide therapy works best in the background of great nutrition, cortisol balance, and the removal of environmental toxins.

The melanocortin system incudes Melanotan II and Bremelanotide (PT-141). Melanotan II increases melanogenesis for photoprotection and increased tanning, plays a role in improving autoimmune disease, eg, Lyme disease. Plays a role in sexual dysfunction and can improve libido (increases sexual arousal) and erectile dysfunction in men (and sexual desire in females) through the CNS, and not through the Cardiovascular System which is the way medicines like Cialis, and Viagra work. Has significant anti-inflammatory disease. Works through the vagal /cholinergic response and affect the immune system.   Can affect appetite and cause weight loss. Works well with intermittent fasting. Activation of the vagus nerve leads to cholinergic signaling and inhibits tumor necrosis factor (TNF) and other pro-inflammatory cytokines overproduction (Cholinergic anti-inflammatory pathway). This pathway is activated by Melanocortin 3R and 4R receptors. This pathway is critical and is significant in anti-inflammation in the brain. This plays a role in neuroprotection and is also cardioprotective, too. The melanocortin system peptides can be used with Thymosin alpha-1 to balance Th1 and Th2 issues. This can also be used with DSIP with Glycine where you can upregulate glutathione peroxidase and superoxide dismutase. This gives us new approaches to autoimmune diseases. Immune cells have melanocortin receptors 1,3,5. Melanocortin receptor 3,4 is in the brain. Melanocortin receptor 4 plays a role in appetite control. The adrenal cortex is melanocortin 2. Alpha melanin-stimulating hormone reacts with all 5 receptors. Melanotan receptor 1 is on the endothelial cell. Melanotan 1 does not cross the blood-brain barrier. Melanotan 2crosses the blood-brain barrier. Melanotan 1 will not give you sexual desire effects but will give you tanning and is responsible for melanogenesis. Melanotan 2 gives you both tanning (sunless tanning) and sexual desire. In women, they can increase pigmentation and more freckles than with men.   Nota bene: The face and hands may get darker than the rest of the body. The use of Melanotan 1 is an art, follow the skin pigmentation to determine dosing adjustments. It has the cosmetic effect of tightening the collagen in the face. Melanotan 1 and Melanotan 2 are effective for autoimmune conditions like Hashimoto’s thyroiditis (may also use Thymosin alpha-1). Psoriasis may also be treated by Melanotan 2, but when treatment is stopped, the disease will come back. Melanotan 2 works through the vagus nerve through the cholinergic anti-inflammatory pathway. Can be useful for Seasonal Allergy because of the anticholinergic effects. Can be used on a daily, or regular basis vs. PT-141 (bremelanotide) which should only be used twice weekly to prevent desensitization. Melanotan 2 is neuroprotective, as well as plays a role in decreasing opioid addiction and ethanol consumption. Melanotan 2 improves libido and erectile dysfunction in men. Melanotan 2 plays a role in appetite and metabolism.

***Caveat emptor (Buyer beware)! Swiss Analytic Labs claims to have tested most if not all peptides advertised on the internet. They say that approximately 80% of these peptides are either adulterated or fake. Be particularly skeptical of marketing for very inexpensive peptide therapies. It simply is impossible for reputable companies to manufacture these products and make money at very low prices. ***

Here are the peptide therapies: 

AOD 9064 stands for Anti-Obesity Drug and is a peptide fragment found within Growth Hormone (the last 15 amino acids),  that is responsible for the substantial weight loss effects that are seen when using Growth Hormone. Growth Hormone causes weight loss of both visceral (deep) fat and retroperitoneal fat, whereas Testosterone and exercise are responsible for the superficial fat loss. Affects lipid metabolism (women greater than men). Best for weight loss of 20-30 pounds.  Promotes chondrocyte production of collagen and proteoglycan. Enhances hyaluronic acid.  The success rate for weight loss improved with work-outs or fasting. It also helps prevent fat build up and increases the NAD+/ NADH ratio, great for the cells and for stem cell renewal. It is best used for weight loss in combination with a Growth Hormone Releasing Hormone (GHRH), and a Growth Hormone Releasing Peptide (GHRP). AOD with HA (hyaluronic acid) useful for cartilage regeneration in knee, hip, shoulder, ankle, and tendinopathies. AOD with HA-also good for trigger point injections.

Examples of GHRH’s include Sermorelin, GRF 1-29, modified GRF 1-29 (CJC-1295 without DAC(makes the pituitary follow the natural pulsatile release to increase Growth Hormone, promotes muscle growth and fat burning and may help with sleep), CJC-1295 with DAC (the DAC-drug affinity complex- increases the half-life of the product by several days and elevates Growth Hormone and IgF1 levels after a single administration), Tesamorelin. Examples of GHRP’s include GHRP-2 (reduces atrophy in muscle, potent stimulator of Growth Hormone secretion, with minimal stimulation of Prolactin and Cortisol, increases growth velocity in children, and improves appetite with weight gain in patients with anorexia ), GHRP-6 (actively increases ghrelin in the stomach, restores Growth Hormone secretion in obesity, and improves phase 2 sleep), Ipamorelin (plays a role in nitrogen retention, the mildest of the group and with large doses does not produce prolactin or cortisol elevations, but does give a large release of Growth Hormone without desensitization side effects ), and Hexarelin (has cardioprotective effects, and the strongest of the group, and gives the biggest pulse of Growth Hormone, but there may be an elevation of prolactin and cortisol transiently, and desensitization can occur regardless of dose so use sparingly).  MK-0677 is fraught with side effects such as involution of receptor sites in the brain and irreversible neurologic damage. It also elevates cortisol and increases depression and anxiety.

The GHRH’s regulate Growth Hormone production and release, the neurochemical regulation of sleep, and much more. The GHRP’s antagonize the release of Somatostatin, and enhances the release of GHRH and increases Growth Hormone release. The GHRP’s also have stress protective benefits, anti-anxiety & anti-depression effects and can stimulate to the production of Nitric Oxide (NO) from endothelial cells. Also has muscle repair function and anti-inflammatory effects.

BPC-157 (Body Protection Compound-157)  by itself does nothing which makes it very safe to use at recommended doses. It has no side effects, no toxicity, and no drug interactions. It helps the body to achieve homeostasis.  It is a powerful cell signaling messenger that decreases inflammation and accelerate healing (muscle, brain, bone, tendon, nerve, ligament, cornea, intestines, as examples). It increases fat loss, improved immune function, well being, and bone mineral density.  Some patients claim that their chronic pain has been substantially reduced. BPC-157 can help you heal faster from injury to bone, muscle, ligament, tendon, nerve, brain, teeth, intestine, cornea via cell signaling. This peptide responds specifically to injury. It also has an influence on neurotransmitters related to stress, anxiety, mood, and behavior via its effects on the serotonergic, dopaminergic, GABAergic and opioid systems. May help with depression.  It has effects on the GI tract via its anti-ulcer, cytoprotective effects. It improves GI mucosal integrity (anecdotal info for healing leaky gut 500mcg, orally, twice daily).  It improves nitric oxide (NO). Useful in weaning patients off Proton Pump Inhibitors (PPI’s) with zinc carnosine over a period of a month. Induces F-actin formation. Can be used after initial use of steroids for acute anti-inflammatory purposes thus prevents the long-term adverse effects of steroid use. Decreases neuroinflammation. Ameliorates alcohol and opioid withdrawal symptoms (may be combined with DSIP), and opposes alcohol intoxication. Helps with homeostasis of dopaminergic and serotoninergic systems.  Improves nerve (axonal and myelin sheath) regeneration. It rapidly and permanently counteracts QTc prolongation of the heart caused by neuroleptic medicines (Haldol, etc) and prokinetics. Intranasal use for Lyme and Mold brain fog.

Cerebrolysin is a neuro-regenerative and neuroprotective peptide. It has neurotrophic repair properties similar to Nerve Growth Factor (NGF) and Brain-Derived Nerve Growth Factor (BDNF). It is a low molecular weight peptide that can cross the blood-brain barrier. Can be used for Traumatic Brain Injury (TBI) and Ocular Migraine Headaches, TIA’s, Stroke, Post Stroke Recovery, and Mood Dysregulation. It can be used to increase memory and learning and can improve synaptic function and synaptic density. Protects nerves from free radicals and oxidative stress damage and improves the metabolic activity of neurons, and protects neurons from neurotoxic effects of glutamate. Improves synaptic functioning.   Enhances cognitive function, memory, learning, creativity, and motivation. It can cross the blood-brain barrier and decreases beta-amyloid formation and deposition as well as Tau protein phosphorylation. It has a positive effect on behavior and neurotrophic stimulation. It can also be used for mood dysregulation, traumatic brain injury (TBI), concussion, stroke, trans-ischemic attacks (TIA), Alzheimer’s disease. In dementia, improves neuronal cytoarchitecture which results in improved cognitive and behavioral performance. Consider doing a trial in those with Apo E 4 (3/4, or 4/4) with cognitive impairment. This can help mitigate the continued cognitive impairment. Significant improvement was seen in those with mild to moderate dementia. 

Deep (or Delta) Sleep Inducing Peptide (DSIP) This peptide not only helps regulate sleep by way of improving the circadian function of sleep (mostly stage 4, slow wave sleep, when growth hormone is released) and decreasing wake ups throughout the night. It is not a sedative drug. It is also neuroprotective (prevents neuronal death) prevents excitotoxicity,  and increases glutathione peroxidase and Superoxide dismutase (SOD) in the brain which increases oxidative phosphorylation in the brain, and hence, improves mitochondrial function and LH release which can boost Testosterone levels by 100-200 points. There are no significant side effects from treatment. Oxidative stress in the brain causes an age-associated decrease in Testosterone. DSIP improves this process in the brain, where it can also help lower feelings of stress by lowering ACTH. This peptide has also been shown to decrease alcohol and opioid withdrawal (and decreases chronic pain). It has a growth hormone releasing response in a physiologic way.

Epithalon literature is mostly from Ukraine and Russia. It regulates the cell cycle to upregulate polymerase activity. The peptide is from the pineal gland, improves the sensitivity of the hypothalamus, and normalizes the function of the anterior pituitary.  It is an anti-aging peptide for short-term use (up to 10 days a year or twice a year). 33% increase in telomere length by inducing telomerase activation and elongation and also prevents chromosome fusion. It is able to overcome the Hayflick limit of cell divisions (by 10 more divisions). Human studies for 12 years, showed decreased mortality by 28%, and a two-fold decrease in cardiovascular mortality. It also has tumor suppression activities. Epithalon combined with Thymalin over a 6 year period decreased the mortality rate 4.1 times that of the control group. In human elderly studies, Epithalon has been shown to increase SOD and Glutathione peroxidase (just like DSIP, and Kisspeptin), complete normalization of antioxidant indices, reduction of lipid peroxide oxidation products, improved melatonin and immunity (both cellular and humoral). Other studies in the elderly showed: increased glucose utilization, increased insulin sensitivity, increased HDL, lowered LDL, lower BP with decreased peripheral resistance, and improved tissue repair. In other human cancer trials: restored cellular immunity, and decreased recurrence and metastasis for 10 years. In breast cancer, patients showed partial or complete tumor regression, improved leukopenia and immune function, and prolonged patient lives.

GHK-Cu (GHK-copper) modulates copper into cells. Can accelerate change from inflammation to a healing phase via decreasing TNF alpha and beta, and decreasing IL-6.   It increases SOD (copper and zinc-dependent) and that leads to a decrease in Reactive Oxygen Species (ROS). Decreases ulcers and infections. Decreases fibrinogen and metastasis of cancer.  Increases myelin and cell regeneration and increase nerve density.  Plays a role in cosmesis and also has been shown to boost self-confidence.

IGF-1 (Insulin-like Growth Factor 1), aka, Somatomedin C.  It’s very similar to insulin. In the brain, it plays a role in neural development and myelination. It is anti-inflammatory. In the heart, it has vasodilatory effects. In muscle, plays a role in muscle development and helps rebuild muscle in a more efficient way. It mediates the effects of Human Growth Hormone. It improves muscle, bone and cartilage tissue. It helps improve connective tissue healing. It plays a role in adipocyte differentiation and regulation. It improves the anti-oxidant defense system. Utility: Conditions needing soft tissue enhancement- muscle, tendon, ligament repair from sports injuries. Looks for specific results over short periods of time. It doesn’t stop the amount of scar tissue made, however (use with TB-4, which decreases scarring). Useful for Diabetes I and Insulin Resistance. It improves insulin sensitivity. Useful for weight loss and metabolic syndrome. Improves bone density. Decreases neural-inflammation.  Low level is associated with CV events and increased mortality rate. It can play a role in those susceptible to cancer so use for short-term, specific uses. High levels are associated with cancer risks (breast -premenopausal-, prostate, colorectal). We are trying to use it in physiological levels only for best results.

Ipamorelin is a Growth Hormone Releasing Peptide (GHRP), anti-depressant, anti-anxiety, protective of stress, potentially neurologically protective.

Kisspeptin 10 was developed in Hershey, PA. (home of the Hershey kiss). This peptide increases Testosterone for men with primary hypogonadism and men who lose Testosterone from the aging process. This peptide works by increasing the pulse frequency and pulse size of LH. Testosterone levels may rise 100-250 points. Kisspeptin 10 has also been shown to be better than HCG for increasing testicular size. There is no feedback inhibition. There is physiologic Growth Hormone release, too.

LL-37 is an antimicrobial peptide classified as a Cathelicidin and is involved with our innate immune system of defense against bacterial invasion, antiviral and antifungal activity on mucous membranes, increases epithelial stiffness and decreases permeability to bacterial invasion; can improve treatment of Cystic Fibrosis. Also, improve treatment for Respiratory Syncytial Virus (RSV) and Influenza A via damaging viral envelope and disruption of viral particles. Has antifibrotic effects and inhibits pro-inflammatory responses of NF kappa beta from LPS (via decrease TNF alpha, and IL-6). Interestingly, it decreases gut permeability via improved tight junctions (claudin, occludins). Can help protect against pathogen-mediated intestinal inflammation. Powerful anti-microbial and anti-inflammatory. Useful in Crohn’s and Ulcerative Colitis. In the Diabetic gut, it improves tight junctions and microflora. With C. difficile, it can decrease inflammation (IL-6).

MGF (mechanical-growth factor) is a peptide in development. It is an isoform of IGF-1 called IGF-1Ec. It is produced locally. It is activated in the heart and the brain by ischemia to activate mRNA coding for the isoform IGF1-Ec. This acts locally to increase anabolism, increase stem cell pool, stimulates satellite cells to make new cells, not grow them as skeletal muscle fibers are unable to divide. MGF expression is significantly increased following mechanical stimuli to muscle, bone, and tendon.  Resistance exercise and skeletal muscle stretch/overload, both contribute to increases in IGF-1Ec. In response to stretching and damage to muscle, MGF is vital for protein synthesis, mRNA transcription, and activation and proliferation of satellite cells. Satellite cells are signaled to replicate by MGF. Satellite cells are prevented from going forward until they fuse with muscle fibers and when they adopt a myogenic program. It’s rapid induction followed by fall of in a couple of days in response to stretching or damage to the muscle, or by ischemia in the brain or heart. This works as a proliferator of cells. This works in concert with Growth HormoneMGF promotes endothelial cell growth. MGF has been shown to improve cardiac function post-MI (myocardial infarction commonly know as a heart attack). It prevents a decrease in left ventricular ejection fraction, reduces post-infarct expansion by inhibiting post-infarct apoptosis (cell death). Helps with the development and repair of neurons. It decreases oxidative stress in the brain as well as NMDA-expressed excitotoxicity. It is also expressed in osteoblasts in response to mechanical stress. MGF reverses sarcopenia. Applications are seen in conditions needing anabolic enhancement, soft tissue repair of ligaments, tendons, muscles from injury; muscle growth; cardiac ischemia problems, brain neuroprotection/ ischemia; age-related sarcopenia. MGF and all IGF’s decline with aging. PEG-MGF is pegylation of MGF and is a peptide in development. It is an attachment of polyethylene glycol to the peptide. The pegylation process acts as a protective coating and stabilizes the MGF molecule.  It protects the MGF molecule from enzymatic and receptor inhibition and increases PEG-MGF half-life to several days (48-72 hours). PEG-MGF is useful in muscle repair or hypertrophy (specific training). The PEG is inert and doesn’t bind to other substances in the body and has rapid urinary excretion. For effects upon muscle, use MGF 600 mcg injected SQ to muscles three times a week to increase proliferation of muscle. The day after the workout you may wish to use IGF1-LR3(100 mcg/ three times a week) that works on the recovery state of muscle. Stay below 2mg total per week.  Don’t use for more than 10 days consecutively and be cautious with hypoglycemia.

Melanotan II isa melanocortin. It works through the brain/ CNS where it causes tanning and naturally makes a woman and a man sexually aroused. Improves libido and erectile dysfunction in men. Caution: may raise blood pressure and may lead to priapism (sustained erection for over an hour) with high doses, and may cause GI upset which may be prevented by coffee, or Xantac.

PT-141 (Bremelanotide) is a melanocortin receptor agonist. Has a high affinity for melanocortin 4 receptors. Improves sexual experiences for men and for women. Improves female sexual dysfunction and erectile dysfunction in males. It acts on the CNS and elicits a more desirous sexual response. GI effects are not as pronounced as with Melanotan 2, but it has been shown that if you do experience nausea, you can use Xantac 150mg, or drink a cup of coffee prophylactically to prevent nausea, or use a lower starting dose prevents nausea. They can also develop some freckles (reversible), even though they are not supposed to become tan with this product (more pronounced in women). Caution: may raise blood pressure, and cause tachycardia, and may cause GI upset.

PEPCK stands for phosphoenolpyruvate carboxykinase. It is an enzyme used in the Krebs Cycle that converts OAA to PEP.  It is involved in the production of gluconeogenesis in the liver and brown and white fat. It plays a role in fat loss, improved performance, and endurance.  If you are trying to improve preformance, you are going to have to improve and adjust lactate threshold and PEPCK helps do this. PEPCK provides a mechanism to control lactate. If you are going to improve the NAD+/NADH ratio of the cell, you are going to increase the efficiency of the cell. PEPCK, fasting, ketone esters, GHRH’s and GHRP’s also improves the NAD+/NADH ratio. This ratio is the ultimate efficiency to evaluate cell function. PEPCK increases glycogen in muscles, decreases muscle fatigue, and increases lactate threshold.

N-Acetyl Semax is a fragment from ACTH. It is not a melanocortin. It is neuroprotective and inhibits histamine release (through its Proline-Glycine-Proline ending sequence). It also reduces vascular permeability.  Nasal spray or SQ. It elevates BDNF in the hippocampus and in the cerebral cortex. It acts as an antidepressant and anxiolytic and attenuates chronic stress. It is a potential melanocortin antagonist (3 and 4 receptors). Other medical uses: Stroke, TIA, Memory, Cognitive Disorders, Boosts Immune System, Peptic Ulcers, Optic Nerve issues. Acts as a brain anti-oxidant. It counteracts the inhibition of learning and memory occurring from toxic heavy metals and counteracts neurotoxic effects. It promotes the survival of neurons secondary to hypoxemia and glutamate neurotoxicity. It contributes to mitochondria stability when under stress. It increases the amount and mobility of immune cells. It can be alternated or mixed with Selank.

Selank shows a variety of effects such as decreased histamine response from mast cells, decreased vascular permeability,  ulcer control meaning increased ulcer healing (from alcohol or stress), allows you to relax and concentrate, helps modulate IL-6, increases brain-derived nerve growth factor (BDNF) in the hippocampus, increases neuroplasticity and stem cell differentiation, has anti-depressant, anxiolytic effects that come on quickly, useful for Generalized Anxiety Disorder (GAD) and shows no sedation/addiction/cognitive loss. has anti-viral activity, regulates inflammation and decreases tumors in breast cancer, helps balance the sleep-wake cycle. Useful to transition from Growth Hormone to using a GHRH/GHRP as it decreases anxiety.

Tesamorelin is a growth hormone releasing hormone (GHRH). It stimulates the release of growth hormone and increases the amplitude of the pulse. It is a fragile peptide so it needs to be refrigerated after being reconstituted and used immediately. Tesamorelin is a good peptide to use if you transition from the use of Growth Hormone to a GHRH (best used with a GHRP, such as Ipamorelin). It has been successfully used to treat HIV + lipodystrophy, as well as to increase lipid metabolism, improve vascular health, control inflammation, and more.

Thymosin alpha-1 modulates innate immunity boosting Natural Killer cells. If you get sore throats and colds multiple times each year, this peptide can help you. This peptide can be used for autoimmune issues in general.  It stimulates T cell production,  decreases the production of pro-inflammatory cytokines, Improves Th1 response, balances Th1/Th2. It dampens immunity (by upregulating IL-10). Enhances dendritic cells, and antibody responses. It has anti-tumor effects and decreases oxidative damage.  It improves tolerance to stress. It increases anti-oxidant and glutathione production.  It improves microcirculation as well as tissue repair and healing. Inhibits viral replication. Applications: improves autoimmune disease, chemical sensitivity,  allergies, cancers, Hepatitis B and C, HIV/AIDS, Malignant Melanoma, and other (particularly stressful situations, eg, air travel, that bring out Shingles, and Seasonal Allergy).  Also, Lyme disease, Chronic Fatigue, Fibromyalgia. Adjuvant to Flu vaccinations in Geriatrics, sepsis, Dysbiosis (along with BPC-157). Best use for Hashimoto’s Thyroiditis is to use daily to lower antibodies (600 mcg/day) instead of every 3 days as used for other conditions. Works well to decrease brain fog of chemo patient (along with BPC-157, and DSIP). There are no documented adverse effects to date (10/20/18).

Thymosin beta4 (TB4) addresses inflammation, immune dysregulation, and reactive oxygen species that underlie chronic illness and age-related decline. Promotes healing via upregulation of G-actin formation. Increases cells involved in healing. Improves cell migration to the site of injury. It decreases scar tissue fibrosis (reduces levels of myofibroblasts). Anti-inflammatory. Promotes angiogenesis and differentiation of endothelial cells. Increases collagen deposition, and is cytoprotective. Improves hair growth. Useful for stroke, and traumatic brain injury (TBI) when used with BPC-157. Also supports immunity and is neuroprotective. Useful for soft tissue repair: tendons, ligaments, muscles, also post-infarction of the myocardium and decreases sarcopenia.  Applications for venous ulcers, and ischemic strokes. Cardioprotective, and useful in Non-Alcoholic Fatty   Liver Disease (NAFLD) by decreasing hepatic fibrosis and decreases proinflammatory factors and oxidative stress. Can be used with BPC-157. Prevents adhesions & fibrous band formation in injured tissue. Protects and restores neurons post-TBI. Works like BPC-157 in that it is a cell-to-cell signaling molecule. Used for patients with sepsis in ICU’s.

Peptide therapy plus Bio-Identical hormones – SynergyPeptides help reclaim the efficiency of receptor sites so they work better (and you won’t need as much hormone to get the effects you seek).

Peptides useful for:

Hormone Optimization, Growth Hormone Secretagogues:  CJC-1295 (without DAC), Ipamorelin, Tesamorelin, GHRP-2, GHRP-6. 

Weight Loss Options: GH-191, GHRP, GHRH/GHRP, AOD-9064, Melanotan II, Frag 176-191 (a knockoff of AOD, not effective), Thymosin alpha-1, Cerebrolysin, DSIP, PEPCK, GLP 1R Agonist. 

Sexual Enhancement and Function: Melanotan II and PT-141.

Healing and Repair: GHK-Cu, BPC-157, Thymosin Beta-4, AOD+ HA, LL-37, GHRH.

Lifestyle & Supplement support for Peptide Therapies: (from lectures by Dr.  Seeds and by Dr.  LaValle)

No smoking or forget doing peptides.

Adequate sleep.

Only PROTEIN within 30 minutes of taking injections.  No fat, or carbs.

Do periodic fasts.

Exercise for best peptide therapy results. Also,  1 hour before workouts, supplements like Phosphatidic acid and works through mTOR signaling (mechanistic Target of Rapamycin) and within 1 hour after workouts (branched-chained amino acids, especially with high levels of the amino acid LEUCINE) for best exercise or stretching results. During workouts, supplement in OJ with L-glutamine,  D-Ribose). The longer the mTOR signaling the longer the net protein synthesis you create. (Ornithine ketoglutarate also works through mTOR signaling).

Creatine: drives tissue anabolism. Great for older people who lack muscle mass.

Arginine: helps make growth hormone (take with Vitamin C) by suppressing somatostatin secretion. Do not take with exercise. You will not make additional growth hormone.

Glutamine: supports GI mucosal integrity, cellular repair, and healing. Supports growth hormone levels.

Alpha-GPC: taken 90 minutes before work outs shown to increase growth hormone levels substantially. How? it increases acetylcholine. Acetylcholine increases the signal release of growth hormone. Improves memory (one of the best supplements available).  Helps to balance the sympathetic and parasympathetic nervous system.


Weight Loss

First and foremost: balance your hormones. Testosterone helps remove superficial fat. Growth Hormone helps remove both visceral (deep) fat and retroperitoneal fat.  However, this is just the start.  As you know, achieving healthy, sustainable weight loss is not so easy. Other factors may be involved such as: food sensitivities, allergies and addictions; neurotransmitter deficiencies, the need for detoxification, reduction of inflammation, sleep deprivation, yeast issues,  the need for effective exercise and other issues that play roles in weight loss.  Each of us has different needs. The aim of our work is for you to succeed in weight loss and having a healthy, toned, slender body.

Second: we offer the Pathway Fit gene testing that determines which kind of diet works best for you (recommendations are individualized and customized) and which kind of exercise program will work best for you to achieve weight loss. The strength of the science for the recommendations is also rated. For example, a 4-star **** gene rating means that there have been over 2,000 people in a study that has been replicated at least once, a 3-star *** gene rating means that a study with at least 400 people has been done that may or may not have been replicated, etc…  The genes not only relate to metabolism but also those that showcase exercise, eating behaviors and other components that can disrupt and sabotage weight loss.  Some of us are, ‘hard-wired to fail’ at diets because we do not have this valuable information that keeps us stuck and prevents us from realizing our weight-loss goals. Knowing the best diet and best exercise program for weight loss based upon your genes gives you the information you need to know to now realize your weight-loss goals.

Here is, “Think you’re weigh thin”, by JJ Virgin. Listen to a fantastic audio that JJ has put together for 20 tips for weight loss. Implement your favorite two or three and start doing them TODAY! Listen to audio.

Third:  detoxification to remove xenoestrogens from the body which prevent you from losing weight (see Gene Testing and Other Testing section for more information about xenoestrogens). Lose the wheat, lose the weight, says New York Times bestselling author Dr. Davis in his book, ‘Wheat Belly’. Dr. Davis states that glidain and wheat germ aglutinin (found in wheat) are toxic to all human beings. Watch video.

Fourth: peptide therapy. The peptide AOD,  which stands for Anti-Obesity Drug, is really a peptide and is a fragment of amino acids found within growth hormone. This peptide plays a role in weight reduction seen in growth hormone. Growth hormone causes reduction of fat in the deep fat and retroperitoneal fat, whereas Testosterone causes a reduction in superficial fat. AOD can be combined with growth hormone releasing hormones (GHRH’s) and growth hormone releasing peptides (GHRP’s). Success is significantly augmented by exercising or fasting. See section on Peptide Therapies for more information.

Finally, the fun and pleasure part: weight loss as a function of pleasure. Do you feel like you are, ‘Stuck in a rut of sitting on your butt’? as Theresa Stevens is often quoted asking. Lose weight by dancing! Theresa further says, “As you love your body, your body will naturally become the body you love.’ To view and to purchase Theresa’s program: Watch video

You may order nutritional supplements from physician-quality manufacturers at the following links below:

  • NEW: we are now using one company that hosts most of the companies below and so ordering is now done under ‘one roof”. Introducing Doctors Supplement Store. You only need to sign up once . You will have access to many of the companies so  you can be selective of the products you need . You will not pay for multiple shipping costs from multiple vendors thus saving you time and money.TO ORDER MANY OF THE PRODUCTS BELOW:  CLICK HERE TO ORDER.
  • ALLERGY RESEARCH GROUP: Excellent products.
  • KLAIRE LABS. Your source for excellent Prebiotic and Probiotic formulas, Digestive Enzymes and more.
  • BIOTICS  RESEARCH CORP. Premier product: Lipid-Sirt, for cholesterol issues and excellent mineral formulas.
  • CAPSOL-T has 100-fold synergy compared to green tea alone.  This product is purported to inhibit the growth and division of cancer cells and not adversely affect normal cells. Useful for elevated PSA.Click here to order.
  • BODY BIO for Phosphatidylcholine & 4:1 oil.  Phosphatidylcholine, called ‘PC’, is the main phospholipid in the cell membranes of the body (a key to longevity!). Here is a fascinating introduction to PC. View here.
  • DESIGNS FOR HEALTH nutritional supplements. This company has activated B-vitamins, Vitamin D3 with Vitamin K (as MK-7). They also offer Annatto, delta/gamma Tocotrienols (100% tocotrienols), which play a significant role in cardiovascular disease prevention.  Use this Patient Referral Code to order (15% off first order): DFH73384  Click here to order from Amazon.com
  • DOUGLAS LABORATORIES nutritional supplements. Wide variety of excellent products including Supercritical CO2 Triglyceride Fish Oil formulation. Call and tell them you are a patient of Dr.Bieley’s.
  • DRUCKER LABS. Makers of INTRAMAX (activated vitamins, minerals, and antioxidants); INTRAMIN (trace minerals), and INTRAKID (activated vitamins, minerals, antioxidants for children).Mention Dr. Bieley and Patient Access Code (PAC) BIE7422 to purchase these fantastic products. Call 888-881-2344 to order directly. Click to order.
  • EMPIRICAL LABS. They offer liposomal Vitamin C, Glutathione, and other nutrients put in unique liposomal vehicles (natural nonhydrogenated phosphatidylcholine) to allow for higher levels of nutrient absorption. Click here to order.
  • ESSENTIAL NUTRITION: This Swiss company offers yummy CHOCOLATE whey protein shakes, and a range of sugar-free products with natural sweeteners. Most popular: their unique ACAI Whey Protein. Use code: BIEHAR16. To order Click here.
  • HUMANN makes of Neo-40 daily. The  wafer is placed on the top of your tongue and increases nitric oxide.This helps vasodilate your vessels, helps with asthma, lowers triglycerides, lowers blood pressure, helps with erections, decreases peripheral neuropathy. Use code ‘healthy’ for 10% off 1st order.Click here.
  • INNATE makes Adrenal Response  containing adaptogenic herbs and holy basil that works on the brain.  Click to order
  • METAGENICS Supplements. Outstanding products, particularly for Hot Flashes and Adrenal Formulations. Click to order
  • XYMOGEN nutritional supplements have unique proprietary products. Very good products, particularly their reformulated B-Activ which can help patients with MTHFR snips. Call Xymogen at 800.647.6100 to place your order and use Dr. Bieley’s personal code, not the code for Doctor’s Supplement Store.
  • NUMEDICA. This company also carries Liposomal Glutathione (the master anti-oxidant of the body), and Vitamin C in a phosphatidylcholine-glycerin complex. Click here to order.
  • THORNE RESEARCH.  Excellent products such as MTHF for people with MTHFR polymorphisms.  They also have excellent detoxification shakes without sugar.
  • LIFE EXTENSION PRODUCTS. Many new and innovative formulations!
  • TRANSFORMATION ENZYMES. If you are gluten sensitive and need to be gluten free, consider CARBO-G.  This product is purported to break down some of the stubborn peptides found in many grains that are implicated in gluten intolerance. Gluten is hidden in many foods and since strict gluten elimination is essential consider this  product.
  • PURE ENCAPSULATIONS Many excellent nutritional supplements! Call them and tell them you are a patient of Dr. Bieley’s.
  • NEOGENIS. Increase nitric oxide by oral supplement. Helps with blood pressure, erectile dysfunction, asthma, and to lower triglycerides!
  • PREVAGEN has a new product for enhanced memory that was initial derived from bioluminescent squid, but the active ingredient is now made from bacteria. For prevention of cognitive decline and for early cognitive issues.
  • READISORB. Oral Liposomal Glutathione to boost your immune system. Also Methyl B-12 and Melatonin in a spray form from Readisorb. Click here to order
  • BENAGENE. Improve blood sugars and exercise endurance with BenaGene. Enter discount code: Bieley33 at the end of the order form for your 10%discount. Click here to view.
  • MYOMIN is a product that competes with xenoestrogens and prevents them from attaching to receptors and causing their disruptive effects. It also helps to prevent estrogen dominance. This product helps both men and women.  . http://chi-health.com/Products/MYOMIN.html
  • ORTHO MOLECULAR PRODUCTS. Features Bergamot product for lowering cholesterol and to improve other lipids. Order from www.fullscript.com

Annatto Tocotrienols are the best source for Tocotrientols and play a significant role in the prevention of cardiovascular disease and much more. See videos from Dr. Barry Tan, Ph.D. on Youtube.  See video. and See another Video.

By measuring your current hormone levels, treating you, and then re-measuring your subsequent hormone levelsthis is the safest method for bringing your hormones into balance. We resolve hormonal imbalance and put things into hormonal balance.

Why Should You Consider BHRT?

Bioidentical hormone replacement therapy helps improve or eliminate hormonally created symptoms, such as PMS symptoms, the symptoms of Andropause (from low male hormones such as testosterone), and the symptoms of menopause misery (the hot flashes, vaginal dryness, night sweats, belly fat, dry skin, memory loss, and fatigue) to improve your energy, memory, mood, and sexual functioning.

We can help you become more stress-resilient to avoid burnout. We can improve the function of your thyroid and can help you normalize TPO antibodies if you suffer from Hashimoto’s thyroiditis, replenish low testosterone, oestrogen, progesterone, DHEA, cortisol, pregnenolone, oxytocin, growth hormone, insulin, parathyroid hormone, and others. We use natural hormones to help create balance, which can protect you from the development of breast cancer or endometrial carcinoma.

We also offer Estrogen Metabolism Gene Testing, which can indicate what abnormal genes you have in estrogen metabolism. Once we discover your vulnerabilities, we can offer you targeted supplements to help re-route estrogen down a healthy pathway, instead of one that predisposes you to developing breast or endometrial cancer.

Gene testing, as we say, is the clarion call, the jarring gong of reality to let you know what your genetic vulnerabilities are, and what we can do about them. By undergoing gene testing, and taking proper action via targeted nutritional supplementation, we can lower the risk of breast cancer.

Who Should Do Gene Testing?

All women have this option offered to them. It is especially important if there is a previous history of breast cancer, or a family history of breast cancer. Of course, if there is an interest, all patients can do this testing now. It’s not especially pricey.

In addition, we not only offer gene testing for estrogen metabolism, but also for heart disease, stroke, and osteoporosis genes. If there is a family history of these conditions, patients are offered this kind of testing at the beginning, or anytime during their treatment. However, we often offer this before the start of bio-identical hormone replacement therapy.

Once these abnormal genes are identified, we can impact their expression through a variety of ways — be it lifestyle modifications, or through supplemental vitamins and minerals that make these pathways work properly.

In addition to these gene tests, we offer poly-pharmacy (multiple medicine) gene testing to see the likelihood of drug/drug interactions that will make the metabolism of the medicines slow down tremendously (consequently making you need less of it to treat your ailment) or speed up significantly (consequently requiring you to adjust your dosage to make them effective).

If you have never felt well, or have bouts of depression throughout your life, we look at your hormones and also offer a total methylation panel gene testing. We may uncover some relevant yet previously unknown connections, and help empower you to overcome these seemingly unsurpassable circumstances.

When we find abnormal genes, called snips (single nucleotide polymorphisms), we can give targeted nutrients that help these genes function better. Along with some proper lifestyle changes, you will have the opportunity to live the life you love.

How BHRT Helps Menopausal Women

Bioidentical hormone therapy for women: It’s not a fun experience to be visited by the ‘Seven dwarves of menopause’ Suzanne Somers wrote about: itchy, bitchy, sweaty, bloaty, sleepy, forgetful, and all dried up!

All the menopause symptoms are really a result of Progesterone deficiency. Supplementation of progesterone will help alleviate these symptoms. We look at all of the sex hormones, in addition to thyroid and adrenals, and by looking and treating the totality of your situation, we have the best chance of obtaining hormonal harmony and balance, and you become yourself again, symptom-free!

Menopausal symptom manifestation in post menopausal women is due to them typically having their ‘tank’ empty, and just flying on fumes. This means their hormone output is low, and they will benefit greatly by replenishing them through bio-identical estrogens (estradiol and estriol, to help alleviate vaginal dryness), bio-identical or natural progesterone therapy (creams or pills), and testosterone (yes, women need it too to help prevent loss of muscle and bone).

It typically takes six to nine months, in general, for hormone replenishment to occur,  and we monitor hormone levels every three months unless there is a special need for earlier testing.

The goal is not only to normalize lab results, but to have you feeling normal, like yourself, again. Remember, you are the patient, and we are treating you — you are not a lab test!

Also, we do not use synthetic estrogens, only bio-identical hormones —  the hormones your body has made all through your life. We also never use oral estrogens, which can increase the risk of gallbladder issues, and they can alter your body lipids in an unfavorable direction.

By sticking to topical application with estrogen creams, or by putting the cream in the vagina, we are able to bypass the liver and avoid these problems. We also, in the appropriate patient, treat with bioidentical hormones after breast cancer treatment.

Although controversial, many women are desperate for symptom relief. In certain groups of women, we can administer them safely with regular monitoring at different times. Clinical trials have shown this can be done safely and effectively.

Bioidentical Hormone Replacement Therapy for Men

Testosterone replacement and key nutrients help men avoid becoming the proverbial ‘grumpy old man.’ These men have a pervasive sense of fatigue and loss of mental and physical sharpness.  

Therapy reverses this, and the effect is a better quality of life. There are multiple ways to increase testosterone in men. We pay particular attention to younger men, as the causes for low testosterone are variable. Treatments offered include Clomid stimulation testing  (Clomiphene) , HCG stimulation testing (human chorionic gonadotropin), and testosterone (creams, gels, injections), and peptide therapies such as Deep or Delta Sleep Inducing Peptide (known as DSIP) and also Kisspeptin.

What is peptide therapy? This treatment sends signals to accelerate your body’s ability to heal, remember, have sexual desire, improve function, and more.

For all men to achieve the beneficial effects of testosterone replacement therapy, their total testosterone levels need to be in the upper quartile of young men.  Being within a ‘normal range’ has not been shown to obtain the beneficial effects of testosterone replacement therapy.

The benefits of testosterone therapy include: decrease in all-cause mortality, decrease in depression symptoms, and decrease in sexual dysfunction (that means good libido, sustainable erections, and orgasm).

Bioidentical Hormone Therapies for Psychological and Psychiatric Issues

For Sleep disorders, Burn-out Syndrome, Sexual Arousal, Depression, slowed progression of Alzheimer’s disease, Irritability & Anxiety, Chronic tendency to Social Withdrawal, Bipolar disorder, and Schizophrenia, the judicious use bio-identical hormones, coupled with targeted nutrient therapy, can be quite helpful.

For women, the benefits of bio-identical hormone therapy include:

  • better energy
  • better memory
  • better mood
  • improved sleep
  • prevention of frailty
  • improved muscles
  • improved bones
  • better heart health
  • improved libido and orgasms
  • better immune function
  • reduced PMS symptoms
  • reduced symptoms of menopause
  • … and more!

For men, if your hormones are out of balance, you may have some or all of the following hormone imbalance symptoms:

  1.    A pervasive sense of fatigue – you feel tired all day!
  2.    Losing mental and/or physical ‘edge’
  3.    ‘Couch potato’ after 5 pm
  4.    Workouts do not produce the results of the past
  5.    Aches and pains (particularly in the neck and shoulders)
  6.    Sexual functioning decreased- unable to obtain or maintain erections, less ejaculate, etc…
  7.    Loss of self-confidence
  8.    Poor sleep
  9.    Less focused thinking
  10. Depression

These symptoms can be reversed with bio-identical hormone replacement therapy. For example, testosterone replacement can sharpen a man’s focus and mental clarity, improve self-esteem and self-confidence, help prevent heart disease by decreasing inflammation, improve blood sugars, helps build bone, helps build muscle, workouts are more productive, and improves sexual functioning.

By combining the work of hormone replacement with nutritional assessments, environmental toxins evaluations, and gene testing for methylation issues and more, we offer you the best chance of becoming well and functioning at your best.

We also offer toxic heavy metals testing and treatment, assessment of environmental toxins, such as mold mycotoxins, and offer modern therapy to remove the offending substance, be it a metal or a mycotoxin.

Once diagnosed, chelation therapy based on the binding coefficient of the metals is offered. If mold mycotoxins are discovered to be present, we offer comprehensive therapy to kill the mold, boost your immune system, boost your overall nutritional status, and decrease the Herxheimer reaction symptoms that often accompany the die-off from the treatment.

These symptoms are usually headache, profound fatigue, stomach discomfort. We further offer brain fitness to quicken your thought processes, and improve your memory. We can add this for men and women as a regular component of their consults.

There are many nutrients, hormones, and other substances that improve  brain processing speed and we routinely take advantage of them, in the course of our consultation with our patients, should they request help in this domain.

The expression “You are only as strong as your weakest part” is demonstrated on a regular basis, so we attempt to address these issues so you can lead a better life.

You have to prime the pump with mild to moderate exercise and high-end nutrition if you want to get the best results with hormones. That means:

  • whey protein or protein with branched-chain amino acids (BCCAs — particularly the amino acid Leucine) in protein shakes with dietary choline of some form to balance the sympathetic vs. parasympathetic nervous system
  • beet crystals to increase nitric oxide to relax the endothelium and lower blood pressure
  • minerals such as magnesium and potassium to get optimal results.

We use functional needs testing and nutritional testing, which include organic acids testing, fatty acids testing, amino acids testing and the functional need for B-vitamins and oxidative stress markets. This kind of testing best predicts what your functional needs requirements are for different nutrients (vitamins and minerals and antioxidants).  

As you can see, bio-identical hormone replacement therapy does not stand alone. It is bolstered by:

  • great nutrition
  • gene testing with supplementation
  • removal of environmental toxins including overbearing stress (we do a thorough evaluation of your adrenals, with questionnaires, and saliva testing)
  • other hormone testing
  • lifestyle modification, which includes getting proper sleep totally necessary for weight loss goals
  • peptide therapies, which is the regenerative part of medicine


Peptide therapies can bolster the effects of hormones and getting well physically, emotionally, and sexually.  

Leave a Reply

Your email address will not be published. Required fields are marked *